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Hippocampus Structure And Function Pdf

hippocampus structure and function pdf

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Published: 27.05.2021

The hippocampus is a part of the brain. It is found in the inner folds of the bottom middle section of the brain, known as the temporal lobe. Humans have known about the hippocampus for more than 4 centuries. It is one of the most studied parts of the brain.

Functional organization of the hippocampal longitudinal axis

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The currently accepted model of a dorsal—ventral posterior—anterior dichotomy of hippocampal function requires revision. Anatomical studies in rodents and primates show that hippocampal extrinsic connectivity is organized as smooth topographical gradients.

The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes. Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers. Furthermore, several types of GABAergic interneurons are present in this region, providing inhibitory control over granule cell activity via feedback and feedforward inhibition.

The brain is an amazing three-pound organ that controls all functions of the body, interprets information from the outside world, and embodies the essence of the mind and soul. Intelligence, creativity, emotion, and memory are a few of the many things governed by the brain. Protected within the skull, the brain is composed of the cerebrum, cerebellum, and brainstem. The brain receives information through our five senses: sight, smell, touch, taste, and hearing - often many at one time. It assembles the messages in a way that has meaning for us, and can store that information in our memory. The brain controls our thoughts, memory and speech, movement of the arms and legs, and the function of many organs within our body.

Linking Hippocampal Structure and Function to Memory Performance in an Aging Population

The limbic system is a convenient way of describing several functionally and anatomically interconnected nuclei and cortical structures that are located in the telencephalon and diencephalon. These nuclei serve several functions, however most have to do with control of functions necessary for self preservation and species preservation. They regulate autonomic and endocrine function, particularly in response to emotional stimuli. They set the level of arousal and are involved in motivation and reinforcing behaviors. Additionally, many of these areas are critical to particular types of memory. Some of these regions are closely connected to the olfactory system, since this system is critical to survival of many species. Areas that are typically included in the limbic system fall into two categories.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The currently accepted model of a dorsal—ventral posterior—anterior dichotomy of hippocampal function requires revision.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Zhao and R. Peng and Shui Ming Wang and L. Wang and Y.

Structure, function, and plasticity of hippocampal dentate gyrus microcircuits

Chapter 9 - Limbic System

T1-weighted image for acquisition of hippocampal volume. The borders of the hippocampus were traced manually in the coronal orientation with simultaneous monitoring for accuracy in the sagittal and axial orthogonal views. Cerebral blood volume CBV maps of the hippocampal formation. B and C, High-resolution T1-weighted images are subsequently acquired before B and after C injection of a contrast agent.

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